Role and expertise of NMI in the proposal
The NMI has gained extensive experience in the development and application of microsystems and nanotechniques for manipulation and analysis of molecules, cells, tissues and biotic-abiotic interfaces. Its core competences in this field are development, fabrication and biotesting of rigid and flexible microelectrode arrays (delivered by MCS to customers worldwide), microfluidic chips, nanostructuring of surfaces (Ebeam/FIB lithography, Nanoimprintig) as well as development and application of analytical techniques (3D Cryo FIB/SEM, SIMS) for characterisation of functional interfaces. The NMI will be responsible for nanostructuring surfaces by Nanoimprinting (WP1), for the integration of nanopatterned surfaces in MEA setups (WP3) and will contribute to the morphological nanoanalysis of the of the cell/substrate contact by 3D Cryo FIB (WP6)
A selection of the most relevant publications from NMI
Greve F, Frerker S, Bittermann AG, Burkhardt C, Hierlemann A, Hall H (2007) Molecular design and characterisation of the neuron-to-bioelectronic-chip interface. Biomaterials, in press
Molina-Luna, K, Buitrago, M.M, Hertler, B, Schubring, M, Haiss, F, Nisch, W, Schulz, J.B, & Luft, A.R. (2007). Cortical stimulation mapping using epidurally implanted thin-film microelectrode arrays. J Neurosci Methods, 161 (1), 118-125.
Stett A, Rudorf R, Stein B, Egert U, Boven K.H, Gottschlich N, Nisch, W. (2005). Perforated polyimide microelectrode arrays for single-cell and tissue recording. In: Mikrosystemtechnik Kongress 2005 (p. 427-430). Hrsg. VDE e.V.; Berlin: VDE, 2005, ISBN 3-8007-2926-1
Bauerdick, S, Burkhardt, C, Kern, D.P, & Nisch, W. (2003). Substrate-integrated microelectrodes with improved charge transfer capacity by 3-dimensional micro-fabrication. Biomedical Microdevices, 5 (2), 93-99
Egert, U, Schlosshauer, B, Fennrich, S, Nisch, W, Fejtl, M, Knott, T, & Haemmerle, H. (1998). A novel organotypic long-term culture of the rat hippocampus on substrate-integrated multielectrode arrays. Brain Research Protocols, 2, 229-242.