Role and expertise of ENS in the proposal
Three research groups of ENS are involved in this project. The group headed by Prof. Yong CHEN will be responsible of WP2 and also actively contribute to WP3, 4, 5, 7 and 9. They will work on various surface patterning techniques, microfluidic devices, stem cell differentiation as well as neuron network forming, based on the existing clean room facilities and cell culture and biochemical processing apparatus. The group leaded by Prof. Christian Amatore will be responsible of WP4, by using their expertise of electrochemical analyses of single cell responses. The group leaded by Prof. Antoine Triller will be responsible of WP5, working on mostly optical characterisation of neuron activities using quantum dots and confocal microscope.The ENS term includes three PI and a number of associates.
A selection of the most relevant publications from ENS
Amatore C, Arbault S, Chen Y, Tapsoba I, Crozatier (2007), Electrochemical Detection of Oxidative Stress on Macrophage Cells in Microfluidic Devices, Lab on a chip 7: 233-238.
Amatore C, Arbault S, Chen Y, Crozatier C, Lemaitre F, Verchier Y (2006), Coupling of electrochemistry and fluorescence microscopy at indium tin oxide microelectrodes for the analysis of single exocytotic events, Angew. Chemie 45 : 4000-4003.
Shi J, Peroz C, Peyrade D, Salari J, Belotti M, Huang HW, Chen Y (2006), Tri-layer soft UV imprint lithography and fabrication of high density pillars, Microelectron. Eng. 83: 1664-1668.
Bouzigues C, Morel M, Triller A and Dahan M (2007) Asymmetric redistribution of GABA receptors during GABA gradient sensing by nerve growth cones analysed by single quantum dot imaging Proc. Natl.Acad. Sci. . 104: 11251-6
Dahan, M, S. Levi, C. Luccardini, P. Rostaing, B. Riveau, and A. Triller.(2003) Diffusion dynamics of glycine receptors revealed by single-quantum dot tracking. Science 302:442-5.