Technical University Denmark
The Technical University of Denmark contributes to the NanoScale project with MIC, the Department of Micro and Nanotechnology with activities in the areas of lab-on-a-chip and nanotechnology; State-of-the-art micro- and nanofabrication facilities in the 1050 m2 DANCHIP clean-room www.danchip.dtu.dk.
The newly established Centre for Electron Nanoscopy (CEN) at DTU (www.cen.dtu.dk), with a world-class collection of electron microscopes; the Biosystems Department at the DTU-RISØ Lab. (www.riso.dtu.dk) has extensive expertise in mathematical, statistical, and computational modelling of cell motility
Role and expertise of DTU in the proposal
Kristian Mølhave/Anja Boisen will be leading WP5. Henrik Flyvbjerg will be leading WP9. MIC has years of experience in nanoimprint lithography, and has developed new techniques based on microchips designed for electron microscopy studies such as nanomanipulation and recently TEM imaging correlated with physical measurements. For WP5 we will use the the instruments at CEN/DTU. For WP 9 we will use the expertise at Risø/DTU where Henrik Flybjerg and Rafael Taboryski has worked on motility analysis and chips for electrophysiological measurements on living biological cells.
A selection of the most relevant publications from the DTU group
David Selmeczi, Stephan Mosler, Peter H. Hagedorn, Niels B. Larsen, and Henrik Flyvbjerg (2007) Cell Motility as Persistent Random Motion: Theories from Experiments. Biophysical Journal Volume 89 August 2005 912-931
David Selmeczi, Liang Li, Lykke I. I. Pedersen, Simon F. Nørrelykke, Peter H. Hagedorn, Stephan Mosler, Niels B. Larsen, Edward C. Cox, and Henrik Flyvbjerg (2007) Cell Motility as Random Motion: A review. Europ. Phys. J. (2007) to appear
Emilia-Laura Munteanu, Anja Lea Olsen, Iva Tolic-Nørrelykke, Henrik Flyvbjerg, Lene Oddershede, and Kirstine Berg-Sørensen (2006) Quantitative Studies of Subdiffusion in Living Cells and Actin Networks. Biophys. Rev. Lett. 1, 411-421
K Mølhave, S B Gudnason, A Tegtmeier Pedersen, C Hyttel Clausen, A Horsewell, P Bøggild (2006) Transmission electron microscopy study of individual carbon nanotube breakdown caused by joule heating in air. Nano Letters 6 1663-1668
K Mølhave, T Wich, A Kortschack, P Bøggild (2006) Pick-and-place nanomanipulation using microfabricated grippers. Nanotechnology 17 2434–2441